Pharmacophore modeling: advances, limitations, and current utility in drug discovery
نویسندگان
چکیده
منابع مشابه
Pharmacophore modeling and applications in drug discovery: challenges and recent advances.
Pharmacophore approaches have become one of the major tools in drug discovery after the past century's development. Various ligand-based and structure-based methods have been developed for improved pharmacophore modeling and have been successfully and extensively applied in virtual screening, de novo design and lead optimization. Despite these successes, pharmacophore approaches have not reache...
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Andrés F. Flórez1,2, Stanley Watowich3 and Carlos Muskus2 1German Cancer Research Center (DKFZ)/ Division Theoretical Systems Biology, Heidelberg 2Universidad de Antioquia/Programa de Estudio y Control de Enfermedades Tropicales – PECET, Medellín 3University of Texas Medical Branch/Department of Biochemistry and Molecular Biology and the Sealy Center for Structural Biology and Molecular Biophys...
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Glucagon and the glucagon receptor are most important molecules control over blood glucose concentrations. These two molecules are very important to studies of type 2 diabetic patients. In literature, several classes of small molecule antagonists of the human glucagon receptor have been reported. Glucagon receptor antagonist could decrease hepatic glucose output and improve glucose control in d...
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Glucagon and the glucagon receptor are most important molecules control over blood glucose concentrations. These two molecules are very important to studies of type 2 diabetic patients. In literature, several classes of small molecule antagonists of the human glucagon receptor have been reported. Glucagon receptor antagonist could decrease hepatic glucose output and improve glucose control in d...
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As structural genomics (SG) projects continue to deposit representative 3D structures of proteins, homology modeling methods will play an increasing role in structure-based drug discovery. Although computational structure prediction methods provide a cost-effective alternative in the absence of experimental structures, developing accurate enough models still remains a big challenge. In this con...
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ژورنال
عنوان ژورنال: Journal of Receptor, Ligand and Channel Research
سال: 2014
ISSN: 1178-699X
DOI: 10.2147/jrlcr.s46843